Biographie et livres d'Andreas Radbruch

Découvrez tout l'univers de l'auteur en livre numérique

Andreas Radbruch did his PhD at the Genetics Institute of the Cologne University, Germany, with Klaus Rajewsky. He later became Associate Professor there and was a visiting scientist with Max Cooper and John Kearney at the University of Alabama, Birmingham. In 1996, he became Director of the German Rheumatism Research Centre Berlin, a Leibniz Institute, and in 1998, Professor of Rheumatology at the Charité, the Medical Faculty of the Humboldt University of Berlin.
A biologist by education, Andreas Radbruch early on worked on somatic variants in myeloma and hybridoma cells lines, modeling antibody class switching and somatic hypermutation. In this context, his lab originally developed the MACS technology. Andreas Radbruch then showed that recombination is the physiological mechanism of class switching in vivo, in plasmablasts isolated ex vivo. Moreover, he could show that in vivo, class switch recombination is targeted to the same Ig class on both IgH loci of a cell, reflecting a tight control of targeting of recombination. An essential element of this control is transcription of recombinogenic sequences, and the processing of these switch (germline) transcripts, as became evident from targeted deletion of the control regions involved. The switch transcripts are induced by cytokines of T helper cells, e.g. interleukin-4. The Radbruch lab contributed essentially to our current understanding of the polarization and imprinting of T helper cells expressing interleukin-4 (Th2) versus those expressing interferon-? (Th1).
The lab then addressed the organization of immunological memory as such. First they identified longlived (memory) plasma cells, mostly residing in bone marrow but also in secondary lymphoid organs and in inflamed tissues. They could show that these cells individually persist in dedicated survival niches, organized by CXCL12-expressing mesenchymal stroma cells. They identified different, dedicated niches for CD4+ and CD8+ memory T cells in the bone marrow, too, and could show that, at least in immune responses to vaccines, memory T cells are mostly maintained in bone marrow, resting in terms of proliferation and gene expression. Thus memory niches organize and maintain memory, and bone provides a privileged environment for resting memory cells. In chronic antibody-mediated diseases, Andreas Radbruch´s lab identified pathogenic antibody-secreting memory plasma cells as critical mediators of chronicity, refractory to conventional immunosuppression, and thus representing a novel therapeutic target. Similarly, in chronic T cell-mediated diseases, the pathogenic T cells induce and adapt to chronicity. Recently, the Radbruch group has identified Twist1, HopX and the microRNAs miR-182 and miR148a as molecular adaptations of proinflammatory T cells to chronicity, and innovative therapeutic targets.
Andreas Radbruch´s work has been recognized by the Carol Nachman Prize for Rheumatology (2011), an Advanced Grant of the European Research Council (ERC, 2010), the Federal Cross of Merit (2008) and the Aronson Award (2000). He is a member of the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW), the European Molecular Biology Organization (EMBO) and the German National Academy of Sciences Leopoldina.

Découvrez tous ses livres

Dernière parution

Molecular Biology of B Cells

Frederick Alt , Tasuku Honjo , Andreas Radbruch , Michael Reth

Academic Press

2014-10-09

PDF, epub sans DRM

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular,...

144,53 €

En savoir plus

Tous les livres numériques d'Andreas Radbruch en PDF et EPUB

2 Livre(s)


Immunotherapy in 2020 Khusru Asadullah , Wolf-Dietrich Döcke , Andreas Radbruch , Hans-Dieter Volk This volume features contributions from participants of the ESRF symposium on Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of... Editeur : Springer Parution : 2007-06-22 PDF, ePub 52,74 € PDF ePub J'achète Téléchargement immédiat Dès validation de votre commande
Current Concepts in Autoimmunity and Chronic Inflammation Peter E. Lipsky , Andreas Radbruch The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is... Editeur : Springer Parution : 2006-09-08 Collection : Current Topics in Microbiology and Immunology PDF 210,99 € J'achète Téléchargement immédiat Dès validation de votre commande

Les livres numériques peuvent être téléchargés depuis votre librairie numérique ou directement depuis une tablette ou smartphone.

PDF : format reprenant la maquette originale du livre ; lecture recommandée sur ordinateur et tablette
EPUB : format de texte repositionnable ; lecture sur tous supports (ordinateur, tablette, smartphone, liseuse)

Votre support de lecture	Format	Application
Ordinateur	-EPUB -PDF	Adobe Digital Editions
Tablette et Smartphone Android	-EPUB -PDF	Adobe Digital Editions pour Android
iPad	-EPUB -PDF	Adobe Digital Editions pour Apple
iPhone	-EPUB	Adobe Digital Editions pour Apple
Liseuse	-EPUB	Module de lecture de la liseuse

Consultez l’aide pour en savoir plus.

Catalogue

Biographie et livres d'Andreas Radbruch

Dernière parution

Tous les livres numériques d'Andreas Radbruch en PDF et EPUB