Télécharger le livre :  Cancer Immunology and Immunotherapy
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies.The present review discusses tumor-immune...

Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Negative Co-Receptors and Ligands
Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or...

Editeur : Springer
Parution : 2011-04-11
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Small-Molecule Inhibitors of Protein-Protein Interactions
In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique...

Editeur : Springer
Parution : 2011-01-18
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease
PI3K has become a very intense area of research, with over 2000 publications onPI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention withPI3K activity are high, and progress in the clinical arena is being monitored by many. However,...

Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Phosphoinositide 3-kinase in Health and Disease
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K...

Editeur : Springer
Parution : 2010-10-17
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Cell Entry by Non-Enveloped Viruses
The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined. Recent findings indicate several members of this group share a common mechanism of membrane penetration in which the virus particle undergoes programmed...

Editeur : Springer
Parution : 2010-09-30
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  The Chemokine System in Experimental and Clinical Hematology
The aim of the issue is to describe and explain the importance of the chemokine system in hematology.The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic...

Editeur : Springer
Parution : 2010-09-30
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Varicella-zoster Virus
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Télécharger le livre :  Diverse Effects of Hypoxia on Tumor Progression
Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged...

Editeur : Springer
Parution : 2010-09-28
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  HIV Interactions with Host Cell Proteins
The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism...

Editeur : Springer
Parution : 2009-12-11
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Immunological Synapse
The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs...

Editeur : Springer
Parution : 2009-12-03
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Molecular Mechanisms of Bacterial Infection via the Gut
Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts as a barrier against microbial invaders and is equipped with various innate defense...

Editeur : Springer
Parution : 2009-10-08
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Autophagy in Infection and Immunity
Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An...

Editeur : Springer
Parution : 2009-10-03
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Dengue Virus
Scientific research on dengue has a long and rich history. The literature has been touched by famous names in medicine- Benjamin Rush, Walter Reed, and Albert Sabin, to name a very few- and has been fertile ground for medical historians . The advances made in those...

Editeur : Springer
Parution : 2009-10-03
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Vaccines for Pandemic Influenza
Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans, resulting in numerous fatalities. The...

Editeur : Springer
Parution : 2009-09-18
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Toll-like Receptors: Roles in Infection and Neuropathology
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been...

Editeur : Springer
Parution : 2009-08-19
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Visualizing Immunity
Researchers have used a variety of techniques over the past century to gain fun- mental insights in the field of immunology and, as technology has advanced, so too has the ability of researchers to delve deeper into the biological mechanics of immunity. The immune...

Editeur : Springer
Parution : 2009-06-12
Collection : Current Topics in Microbiology and Immunology ePub

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Télécharger le livre :  Measles
Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous...

Editeur : Springer
Parution : 2008-10-30
Collection : Current Topics in Microbiology and Immunology PDF

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Télécharger le livre :  Advances in Multiple Sclerosis and Experimental Demyelinating Diseases
Controversy still exists regarding how early disease-modifying agents (DMA) should be commenced and whether all patients with relapsing-remitting MS should in fact be treated. To answer these questions, it is also important to know the natural history of the disease. MS...

Editeur : Springer
Parution : 2007-12-24
Collection : Current Topics in Microbiology and Immunology PDF

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Télécharger le livre :  Interferon: The 50th Anniversary
Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a...

Editeur : Springer
Parution : 2007-08-29
Collection : Current Topics in Microbiology and Immunology PDF

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