Téléchargez le livre : Inflammasomes: Clinical and Therapeutic Implications

Inflammasomes: Clinical and Therapeutic Implications

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Éditeur :

Springer


Collection :

Experientia Supplementum

Paru le : 2018-09-04

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Description

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1ß and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1ß has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Pages
400 pages
Collection
Experientia Supplementum
Parution
2018-09-04
Marque
Springer
EAN papier
9783319893891
EAN PDF
9783319893907
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
40
Taille du fichier
8182 Ko
Prix
147,69 €
EAN EPUB
9783319893907
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
40
Taille du fichier
14653 Ko
Prix
147,69 €

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