Téléchargez le livre : Structure-based Ligand Design
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Description
Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships.

This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid.

The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery.
Pages
167 pages
Collection
Methods & Principles in Medicinal Chemistry
Parution
2008-11-21
Marque
Wiley-VCH
EAN papier
9783527293438
EAN PDF
9783527612161
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
167
Taille du fichier
25395 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
125,23 €

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