Téléchargez le livre : Protein-Protein Interactions in Drug Discovery
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Description
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.
The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.

From the contents:

* Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies
* Modulators of protein-protein interactions: The importance of Three-Dimensionality
* Interactive technologies for leveraging the known chemistry of anchor residues
* SH3 Domains as Drug Targets
* P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments
* Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases
* The PIF-binding pocket of AGC kinases
* Peptidic inhibitors of protein-protein interactions for cell adhesion receptors
* The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases

and more
Pages
334 pages
Collection
Methods & Principles in Medicinal Chemistry
Parution
2013-01-02
Marque
Wiley-VCH
EAN papier
9783527331079
EAN PDF
9783527648238
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
334
Taille du fichier
17121 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
178,82 €
EAN EPUB
9783527648221
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
334
Taille du fichier
5366 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
178,82 €

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