Téléchargez le livre : Bioisosteres in Medicinal Chemistry
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Description
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Pages
256 pages
Collection
Methods & Principles in Medicinal Chemistry
Parution
2012-06-18
Marque
Wiley-VCH
EAN papier
9783527330157
EAN PDF
9783527654338
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
256
Taille du fichier
13640 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
160,99 €
EAN EPUB
9783527654321
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
256
Taille du fichier
2796 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
160,99 €

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