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Protein Interactions

Biophysical Approaches for the Study of Complex Reversible Systems

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Éditeur :

Springer


Collection :

Protein Reviews

Paru le : 2007-03-20



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Description
When I was invited to edit this volume, I wanted to take the opportunity to assemble reviews of different biophysical methodologies for protein interactions at a level suf?ciently detailed to understand how complex systems can be studied. There are several excellent introductory texts for biophysical methodologies, many with hands-on descriptions or embedded in general introductions to physical b- chemistry. The goal of the present volume was to present state-of-the-art reviews that do not necessarily enable the reader to carry out these techniques, but to gain a deep understanding of the biophysical observables, to stimulate creative thought on how the techniques may be applied to study a particular biological system, and to foster collaboration and multidisciplinary work. Reversible protein interactions involve noncovalent chemical bonds, pro- cing protein complexes with free energies not far from the order of magnitude of the thermal energy kT. As a consequence, they can be highly dynamic and may be controlled, for example, by protein expression levels and changes in the intracel- lar or microenvironment. Reversible protein complexes may have suf?cient stab- ity to be puri?ed for study, but frequently their short lifetime essentially limits their existence to solutions of mixtures of the binding partners in which they remain populated through dissociation and reassociation processes. To understand the function of such protein complexes, it is important to study their structure and dynamics.
Pages
532 pages
Collection
Protein Reviews
Parution
2007-03-20
Marque
Springer
EAN papier
9780387359656
EAN PDF
9780387359663
Informations sur l'ebook
Nombre pages copiables
5
Nombre pages imprimables
53
Taille du fichier
31386 Ko
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Prix
210,99 €

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