Téléchargez le livre : Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B

Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B



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Éditeur :

Springer


Collection :

Springer Theses

Paru le : 2012-01-15



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Description
In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Pages
222 pages
Collection
Springer Theses
Parution
2012-01-15
Marque
Springer
EAN papier
9783642271946
EAN EPUB
9783642271953
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
22
Taille du fichier
4598 Ko
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Prix
94,94 €

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